Progress towards understanding the genetics of posttraumatic stress disorder

Voisey, Joanne, Young, Ross McD., Lawford, Bruce R., & Morris, Charles P. (2014) Progress towards understanding the genetics of posttraumatic stress disorder. Journal of Anxiety Disorders, 28(8), pp. 873-883.

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Abstract

Posttraumatic stress disorder (PTSD) is a complex syndrome that occurs following exposure to a potentially life threatening traumatic event. This review summarises the literature on the genetics of PTSD including gene–environment interactions (GxE), epigenetics and genetics of treatment response. Numerous genes have been shown to be associated with PTSD using candidate gene approaches. Genome-wide association studies have been limited due to the large sample size required to reach statistical power. Studies have shown that GxE interactions are important for PTSD susceptibility. Epigenetics plays an important role in PTSD susceptibility and some of the most promising studies show stress and child abuse trigger epigenetic changes. Much of the molecular genetics of PTSD remains to be elucidated. However, it is clear that identifying genetic markers and environmental triggers has the potential to advance early PTSD diagnosis and therapeutic interventions and ultimately ease the personal and financial burden of this debilitating disorder.

Impact and interest:

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3 citations in Web of Science®

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ID Code: 78051
Item Type: Journal Article
Refereed: Yes
Keywords: anxiety, PTSD, genetics, epigenetics, trauma
DOI: 10.1016/j.janxdis.2014.09.014
ISSN: 0887-6185
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Epigenetics (incl. Genome Methylation and Epigenomics) (060404)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Psychiatry (incl. Psychotherapy) (110319)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
Copyright Owner: Copyright 2014 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Journal of Anxiety Disorders. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Anxiety Disorders, [VOL 28, ISSUE 8, (2014)] DOI: 10.1016/j.janxdis.2014.09.014
Deposited On: 27 Oct 2014 22:59
Last Modified: 26 Oct 2015 21:16

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