Functions and therapeutic roles of exosomes in cancer

Tickner, Jacob A, Urquhart, Aaron J., Stephenson, Sally-Anne, Richard, Derek J., & O'Byrne, Kenneth J. (2014) Functions and therapeutic roles of exosomes in cancer. Frontiers in Oncology, 4, pp. 127-1.

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The role of exosomes in cancer development has become the focus of much research, due to the many emerging roles possessed by exosomes. These micro-vesicles that are ubiquitously released in to the extracellular milieu, have been found to regulate immune system function, particularly in tumorigenesis, as well as conditioning future metastatic sites for the attachment and growth of tumor tissue. Through an interaction with a range of host tissue, exosomes are able to generate a pro-tumor environment that is essential for carcinogenesis. Herein, we discuss the contents of exosomes and their contribution to tumorigenesis, as well as their role in chemotherapeutic resistance and the development of novel cancer treatments and the identification of cancer biomarkers.

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ID Code: 78359
Item Type: Journal Article
Refereed: No
Additional Information: Tickner, Jacob A
Urquhart, Aaron J
Stephenson, Sally-Anne
Richard, Derek J
O'Byrne, Kenneth J
Front Oncol. 2014 May 27;4:127. doi: 10.3389/fonc.2014.00127. eCollection 2014.
Keywords: exosome, cancer, metastatic niche, chemotherapeutic resistance, biomarker
DOI: 10.3389/fonc.2014.00127
ISSN: 2234-943X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 03 Nov 2014 05:09
Last Modified: 14 Jun 2015 22:27

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