An organization of visual and auditory fear conditioning in the lateral amygdala

Bergstrom, Hadley C. & Johnson, Luke R. (2014) An organization of visual and auditory fear conditioning in the lateral amygdala. Neurobiology of Learning and Memory, 116, pp. 1-13.

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Abstract

Pavlovian fear conditioning is an evolutionary conserved and extensively studied form of associative learning and memory. In mammals, the lateral amygdala (LA) is an essential locus for Pavlovian fear learning and memory. Despite significant progress unraveling the cellular mechanisms responsible for fear conditioning, very little is known about the anatomical organization of neurons encoding fear conditioning in the LA. One key question is how fear conditioning to different sensory stimuli is organized in LA neuronal ensembles. Here we show that Pavlovian fear conditioning, formed through either the auditory or visual sensory modality, activates a similar density of LA neurons expressing a learning-induced phosphorylated extracellular signal-regulated kinase (p-ERK1/2). While the size of the neuron population specific to either memory was similar, the anatomical distribution differed. Several discrete sites in the LA contained a small but significant number of p-ERK1/2-expressing neurons specific to either sensory modality. The sites were anatomically localized to different levels of the longitudinal plane and were independent of both memory strength and the relative size of the activated neuronal population, suggesting some portion of the memory trace for auditory and visually cued fear conditioning is allocated differently in the LA. Presenting the visual stimulus by itself did not activate the same p-ERK1/2 neuron density or pattern, confirming the novelty of light alone cannot account for the specific pattern of activated neurons after visual fear conditioning. Together, these findings reveal an anatomical distribution of visual and auditory fear conditioning at the level of neuronal ensembles in the LA.

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ID Code: 78649
Item Type: Journal Article
Refereed: Yes
Keywords: Brain mapping, Memory strength, Basolateral amygdala, Memory consolidation, Microcircuit, Neuronal ensemble, Threat conditioning
DOI: 10.1016/j.nlm.2014.07.008
ISSN: 1074-7427
Subjects: Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Biological Psychology (Neuropsychology Psychopharmacology Physiological Psychology) (170101)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Sensory Processes Perception and Performance (170112)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
Copyright Owner: Copyright 2014 [please consult the authors]
Copyright Statement: NOTICE: this is the author’s version of a work that was accepted for publication in Neurobiology of Learning and Memory. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neurobiology of Learning and Memory, Volume 116, (December 2014), DOI: 10.1016/j.nlm.2014.07.008
Deposited On: 26 Nov 2014 22:58
Last Modified: 04 Jan 2016 14:25

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