Double-strand breaks and the concept of short- and long-term epigenetic memory

Orlowski, Christian, Mah, Li-Jeen, Vasireddy, Raja S., El-Osta, Assam, & Karagiannis, Tom C. (2011) Double-strand breaks and the concept of short- and long-term epigenetic memory. Chromosoma, 120(2), pp. 129-149.

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Abstract

Double-strand breaks represent an extremely cytolethal form of DNA damage and thus pose a serious threat to the preservation of genetic and epigenetic information. Though it is well-known that double-strand breaks such as those generated by ionising radiation are among the principal causative factors behind mutations, chromosomal aberrations, genetic instability and carcino-genesis, significantly less is known about the epigenetic consequences of double-strand break formation and repair for carcinogenesis. Double-strand break repair is a highly coordinated process that requires the unravelling of the compacted chromatin structure to facilitate repair machinery access and then restoration of the original undamaged chromatin state. Recent experimental findings have pointed to a potential mechanism for double-strand break-induced epigenetic silencing. This review will discuss some of the key epigenetic regulatory processes involved in double-strand break (DSB) repair and how incomplete or incorrect restoration of chromatin structure can leave a DSB-induced epigenetic memory of damage with potentially pathological repercussions

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9 citations in Scopus
8 citations in Web of Science®
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ID Code: 78879
Item Type: Journal Article
Refereed: Yes
Keywords: Oncology, Carcinogenesis, DNA, double-strand breaks, mutations, genetic instability, chromosomal aberrations
DOI: 10.1007/s00412-010-0305-6
ISSN: 1432-0886
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 24 Nov 2014 01:28
Last Modified: 23 Jun 2017 08:02

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