The current state of play in human neural stem cell models : what we have learnt from the rodent

Oikari, L., Griffiths, L., & Haupt, L. (2014) The current state of play in human neural stem cell models : what we have learnt from the rodent. OA Stem Cells, 2(1), p. 7.

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Abstract

Rodent (mouse and rat) models have been crucial in developing our understanding of human neurogenesis and neural stem cell (NSC) biology. The study of neurogenesis in rodents has allowed us to begin to understand adult human neurogenesis and in particular, protocols established for isolation and in vitro propagation of rodent NSCs have successfully been applied to the expansion of human NSCs. Furthermore, rodent models have played a central role in studying NSC function in vivo and in the development of NSC transplantation strategies for cell therapy applications. Rodents and humans share many similarities in the process of neurogenesis and NSC biology however distinct species differences are important considerations for the development of more efficient human NSC therapeutic applications. Here we review the important contributions rodent studies have had to our understanding of human neurogenesis and to the development of in vitro and in vivo NSC research. Species differences will be discussed to identify key areas in need of further development for human NSC therapy applications.

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ID Code: 78966
Item Type: Review
Refereed: Yes
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 The Author(s)
Copyright Statement: The final HTML/PDF is also available at http://www.oapublishinglondon.com
Deposited On: 26 Nov 2014 23:14
Last Modified: 29 Nov 2014 08:07

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