Mathematical modelling of intramembranous bone formation during fracture healing

Manitzky, Louise J. (2014) Mathematical modelling of intramembranous bone formation during fracture healing. PhD thesis, Queensland University of Technology.


During fracture healing, many complex and cryptic interactions occur between cells and bio-chemical molecules to bring about repair of damaged bone. In this thesis two mathematical models were developed, concerning the cellular differentiation of osteoblasts (bone forming cells) and the mineralisation of new bone tissue, allowing new insights into these processes. These models were mathematically analysed and simulated numerically, yielding results consistent with experimental data and highlighting the underlying pattern formation structure in these aspects of fracture healing.

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ID Code: 78983
Item Type: QUT Thesis (PhD)
Supervisor: Pettet, Graeme & Farrell, Troy
Keywords: Fracture Healing, Intramembranous Bone Formation, Mathematical Modelling, Mineralisation, Osteoblast differentiation, Turing Patterns
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 17 Dec 2014 04:38
Last Modified: 08 Sep 2015 06:50

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