γ-radiation-induced γH2AX formation occurs preferentially in actively transcribing euchromatic loci

Vasireddy, Raja S., Karagiannis, Tom C., & El-Osta, Assam (2010) γ-radiation-induced γH2AX formation occurs preferentially in actively transcribing euchromatic loci. Cellular and Molecular Life Sciences, 67(2), pp. 291-294.

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Abstract

The central dogma in radiation biology is that nuclear DNA is the critical target with respect to radiosensitivity. In accordance with the theoretical expectations, and in the absence of a conclusive model, the general consensus in the field has been to view chromatin as a homogeneous template for DNA damage and repair. This paradigm has been called into question by recent findings indicating a disparity in γ-irradiation-induced γH2AX foci formation in euchromatin and heterochromatin. Here, we have extended those studies and provide evidence that γH2AX foci form preferentially in actively transcribing euchromatin following γ-irradiation.

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16 citations in Scopus
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14 citations in Web of Science®

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ID Code: 79005
Item Type: Journal Article
Refereed: Yes
Keywords: Euchromatin, Heterochromatin, Histone methylation, γH2AX, Double strand break, γ-Radiation
DOI: 10.1007/s00018-009-0181-5
ISSN: 1420-9071
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 30 Nov 2014 23:15
Last Modified: 02 Dec 2014 01:29

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