Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens

Ratheesh, Aparna, Gomez, Guillermo A., Priya, Rashmi, Verma, Suzie, Kovacs, Eva M., Jiang, Kai, Brown, Nicholas H., Akhmanova, Anna, Stehbens, Samantha J., & Yap, Alpha S. (2012) Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nature Cell Biology, 14(8), pp. 818-828.

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Abstract

The biological impact of Rho depends critically on the precise subcellular localization of its active, GTP-loaded form. This can potentially be determined by the balance between molecules that promote nucleotide exchange or GTP hydrolysis. However, how these activities may be coordinated is poorly understood. We now report a molecular pathway that achieves exactly this coordination at the epithelial zonula adherens. We identify an extramitotic activity of the centralspindlin complex, better understood as a cytokinetic regulator, which localizes to the interphase zonula adherens by interacting with the cadherin-associated protein, α-catenin. Centralspindlin recruits the RhoGEF, ECT2, to activate Rho and support junctional integrity through myosin IIA. Centralspindlin also inhibits the junctional localization of p190 B RhoGAP, which can inactivate Rho. Thus, a conserved molecular ensemble that governs Rho activation during cytokinesis is used in interphase cells to control the Rho GTPase cycle at the zonula adherens

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93 citations in Web of Science®

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ID Code: 79006
Item Type: Journal Article
Refereed: Yes
Keywords: RHO Signalling, GTP hydrolysis, epithelial zonula adherans
DOI: 10.1038/ncb2532
ISSN: 1476-4679
Subjects: Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 02 Dec 2014 00:18
Last Modified: 03 Dec 2014 01:40

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