Targeting and transport : how microtubules control focal adhesion dynamics
Stehbens, Samantha & Wittmann, Torsten (2012) Targeting and transport : how microtubules control focal adhesion dynamics. The Journal of Cell Biology, 198(4), pp. 481-489.
Directional cell migration requires force generation that relies on the coordinated remodeling of interactions with the extracellular matrix (ECM), which is mediated by integrin-based focal adhesions (FAs). Normal FA turnover requires dynamic microtubules, and three members of the diverse group of microtubule plus-end-tracking proteins are principally involved in mediating microtubule interactions with FAs. Microtubules also alter the assembly state of FAs by modulating Rho GTPase signaling, and recent evidence suggests that microtubule-mediated clathrin-dependent and -independent endocytosis regulates FA dynamics. In addition, FA-associated microtubules may provide a polarized microtubule track for localized secretion of matrix metalloproteases (MMPs). Thus, different aspects of the molecular mechanisms by which microtubules control FA turnover in migrating cells are beginning to emerge.
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|Item Type:||Journal Article|
|Additional Information:||Articles free to read on journal website after 6 months|
|Keywords:||animals, endocytosis, extracellular matrix, focal adhesions, microtubules, signal transduction, humans|
|Subjects:||Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400)|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||02 Dec 2014 00:03|
|Last Modified:||05 Feb 2015 00:27|
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