Targeting and transport : how microtubules control focal adhesion dynamics

Stehbens, Samantha & Wittmann, Torsten (2012) Targeting and transport : how microtubules control focal adhesion dynamics. The Journal of Cell Biology, 198(4), pp. 481-489.

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Abstract

Directional cell migration requires force generation that relies on the coordinated remodeling of interactions with the extracellular matrix (ECM), which is mediated by integrin-based focal adhesions (FAs). Normal FA turnover requires dynamic microtubules, and three members of the diverse group of microtubule plus-end-tracking proteins are principally involved in mediating microtubule interactions with FAs. Microtubules also alter the assembly state of FAs by modulating Rho GTPase signaling, and recent evidence suggests that microtubule-mediated clathrin-dependent and -independent endocytosis regulates FA dynamics. In addition, FA-associated microtubules may provide a polarized microtubule track for localized secretion of matrix metalloproteases (MMPs). Thus, different aspects of the molecular mechanisms by which microtubules control FA turnover in migrating cells are beginning to emerge.

Impact and interest:

74 citations in Scopus
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68 citations in Web of Science®

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ID Code: 79007
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after 6 months
Keywords: animals, endocytosis, extracellular matrix, focal adhesions, microtubules, signal transduction, humans
DOI: 10.1083/jcb.201206050
ISSN: 1540-8140
Subjects: Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 02 Dec 2014 00:03
Last Modified: 05 Feb 2015 00:27

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