Targeting and transport : how microtubules control focal adhesion dynamics

Stehbens, Samantha & Wittmann, Torsten (2012) Targeting and transport : how microtubules control focal adhesion dynamics. The Journal of Cell Biology, 198(4), pp. 481-489.

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Directional cell migration requires force generation that relies on the coordinated remodeling of interactions with the extracellular matrix (ECM), which is mediated by integrin-based focal adhesions (FAs). Normal FA turnover requires dynamic microtubules, and three members of the diverse group of microtubule plus-end-tracking proteins are principally involved in mediating microtubule interactions with FAs. Microtubules also alter the assembly state of FAs by modulating Rho GTPase signaling, and recent evidence suggests that microtubule-mediated clathrin-dependent and -independent endocytosis regulates FA dynamics. In addition, FA-associated microtubules may provide a polarized microtubule track for localized secretion of matrix metalloproteases (MMPs). Thus, different aspects of the molecular mechanisms by which microtubules control FA turnover in migrating cells are beginning to emerge.

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68 citations in Web of Science®

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ID Code: 79007
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after 6 months
Keywords: animals, endocytosis, extracellular matrix, focal adhesions, microtubules, signal transduction, humans
DOI: 10.1083/jcb.201206050
ISSN: 1540-8140
Subjects: Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 02 Dec 2014 00:03
Last Modified: 05 Feb 2015 00:27

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