Microtubules and cadherins : a neglected partnership

Stehbens, Samantha, J., Akhmanova, Anna, & Yapp, Alpha S. (2009) Microtubules and cadherins : a neglected partnership. Frontiers in Bioscience, 14, pp. 3159-3167.

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Classical cadherins are fundamental determinants of tissue organization both in health and disease. It has long been recognized that cadherins function in close cooperation with the cytoskeleton, particularly with actin. Less appreciated is the capacity for cadherins to also interact functionally and biochemically with microtubules and their associated proteins. In this review, we aim to highlight the potential for cooperativity between cadherins and microtubules. Cadherins can regulate the organization and dynamics of microtubules through mechanisms such as anchorage of minus ends and cortical capture of plus ends. Such cadherin-induced reorganization of microtubules may then affect cadherin biology by diverse processes that include directed vesicular traffic by microtubule-based motors and regulation of cortical signaling and organization. Ultimately, we hope this will stimulate fresh interest and research to understand a neglected partnership.

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21 citations in Web of Science®

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ID Code: 79011
Item Type: Journal Article
Refereed: Yes
Keywords: Adherens junction, Cell-cell contact, E-cadherin, Epithelia, Microtubule
DOI: 10.2741/3442
ISSN: 1093-4715
Subjects: Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 01 Dec 2014 23:30
Last Modified: 27 Jan 2015 02:36

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