Updates in inducible transgene expression using viral vectors : from transient to stable expression

Mortimer, Cara L., Dugdale, Benjamin, & Dale, James L. (2015) Updates in inducible transgene expression using viral vectors : from transient to stable expression. Current Opinion in Biotechnology, 32, pp. 85-92.

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The prospect of economically producing useful biologics in plants has greatly increased with the advent of viral vectors. The ability of viral vectors to amplify transgene expression has seen them develop into robust transient platforms for the high-level, rapid production of recombinant proteins. To adapt these systems to stably transformed plants, new ways of deconstructing the virus machinery and linking its expression and replication to chemically controlled promoters have been developed. The more advanced of these stable, inducible hyper-expression vectors provide both activated and amplified heterologous transgene expression. Such systems could be deployed in broad acre crops and provide a pathway to fully exploit the advantages of plants as a platform for the manufacture of a wide spectrum of products.

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ID Code: 79132
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.copbio.2014.11.009
ISSN: 0958-1669
Subjects: Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > AGRICULTURAL BIOTECHNOLOGY (100100) > Agricultural Biotechnology not elsewhere classified (100199)
Divisions: Current > Research Centres > Centre for Tropical Crops and Biocommodities
Current > Schools > School of Earth, Environmental & Biological Sciences
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2015 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Current Opinion in Biotechnology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Current Opinion in Biotechnology, [VOL 32, (2015)] DOI: 10.1016/j.copbio.2014.11.009
Deposited On: 02 Dec 2014 05:23
Last Modified: 12 May 2016 01:34

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