Tissue-engineered 3D tumor angiogenesis models : potential technologies for anti-cancer drug discovery

Chwalek, Karolina, Bray, Laura J., & Werner, Carsten (2014) Tissue-engineered 3D tumor angiogenesis models : potential technologies for anti-cancer drug discovery. Advanced Drug Delivery Reviews, 79-80, pp. 30-39.

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Angiogenesis is indispensable for solid tumor expansion, and thus it has become a major target of cancer research and anti-cancer therapies. Deciphering the arcane actions of various cell populations during tumor angiogenesis requires sophisticated research models, which could capture the dynamics and complexity of the process. There is a continuous need for improvement of existing research models, which engages interdisciplinary approaches of tissue engineering with life sciences. Tireless efforts to develop a new model to study tumor angiogenesis result in innovative solutions, which bring us one step closer to decipher the dubious nature of cancer. This review aims to overview the recent developments, current limitations and future challenges in three-dimensional tissue-engineered models for the study of tumor angiogenesis and for the purpose of elucidating novel targets aimed at anti-cancer drug discovery.

Impact and interest:

19 citations in Scopus
19 citations in Web of Science®
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ID Code: 79200
Item Type: Journal Article
Refereed: Yes
Keywords: 3D cell culture, Cancer
DOI: 10.1016/j.addr.2014.05.006
ISSN: 0169-409X
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Advanced Drug Delivery Reviews. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Advanced Drug Delivery Reviews, [VOL 79-80, (2014)] DOI: 10.1016/j.addr.2014.05.006
Deposited On: 03 Dec 2014 23:48
Last Modified: 02 Jan 2016 05:30

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