Reduced motor facilitation during action observation in schizophrenia : a mirror neuron deficit?

Enticott, Peter G., Hoy, Kate E., Herring, Sally E., Johnston, Patrick J., Daskalakis, Zafiris J., & Fitzgerald, Paul B. (2008) Reduced motor facilitation during action observation in schizophrenia : a mirror neuron deficit? Schizophrenia Research, 102(1-3), pp. 116-121.

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Abstract

Impairments in social cognitive functioning are well documented in schizophrenia, however the neural basis of these deficits is unclear. A recent explanatory model of social cognition centers upon the activity of mirror neurons, which are cortical brain cells that become active during both the performance and observation of behavior. Here, we test for the first time whether mirror neuron functioning is reduced in schizophrenia. Fifteen individuals with schizophrenia or schizoaffective disorder and fifteen healthy controls completed a transcranial magnetic stimulation (TMS) experiment designed to assess mirror neuron activation. While patients demonstrated no abnormalities in cortical excitability, motor facilitation during action observation, putatively reflecting mirror neuron activity, was reduced in schizophrenia. Dysfunction within the mirror neuron system may contribute to the pathophysiology of schizophrenia.

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29 citations in Scopus
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46 citations in Web of Science®

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ID Code: 79437
Item Type: Journal Article
Refereed: Yes
Keywords: schizophrenia, social cognition, mirror neurons, transcranial magnetic stimulation, primary motor cortex, premotor cortex
DOI: 10.1016/j.schres.2008.04.001
ISSN: 0920-9964
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Psychiatry (incl. Psychotherapy) (110319)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Biological Psychology (Neuropsychology Psychopharmacology Physiological Psychology) (170101)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Sensory Processes Perception and Performance (170112)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
Deposited On: 22 Jan 2015 00:26
Last Modified: 06 Feb 2015 01:57

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