An SECM study on the influence of cationic, membrane-active peptides on a gold-supported self-assembled monolayer
Abdelhamid, Muhammad E., Piantavigna, Stefania, Bond, Alan M., Graham, Bim, Spiccia, Leone, Martin, Lisandra L., & O'Mullane, Anthony P. (2015) An SECM study on the influence of cationic, membrane-active peptides on a gold-supported self-assembled monolayer. Electrochemistry Communications, 51, pp. 11-14.
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The influence of the membrane active peptides, Tat44–57 (activator in HIV-1) and melittin (active content of bee venom), on self-assembled monolayers of 6-mercaptohexanoic acid (MHA) on gold electrodes has been studied with scanning electrochemical microscopy (SECM). It was found that MHA, when deprotonated at physiological pH, significantly affected the relative rates of electron transfer between the [Fe(CN)6]4− solution based mediator and the underlying gold electrode, predominantly by the electrostatic interaction between the mediator and MHA. Upon the introduction of Tat44–57 ormelittin to the electrolyte, the relative rate of electron transfer through the MHA layer could be increased or decreased depending on the mediator used. However, in all cases it was found that these peptides have the ability to be incorporated into synthetic SAMs, which has implications for future electrochemical studies carried out using cell mimicking membranes immobilised on such layers.
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|Item Type:||Journal Article|
|Keywords:||Scanning electrochemical microscopy, Self-assembled monolayers, Peptides, Electron transfer, Electrochemistry|
|Subjects:||Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > PHYSICAL CHEMISTRY (INCL. STRUCTURAL) (030600) > Electrochemistry (030604)|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2014 Elsevier B.V.|
|Copyright Statement:||NOTICE: this is the author’s version of a work that was accepted for publication in Electrochemistry Communications. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Electrochemistry Communications, Volume 51, February 2015, DOI: 10.1016/j.elecom.2014.11.018|
|Deposited On:||17 Dec 2014 05:03|
|Last Modified:||20 Dec 2014 05:24|
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