Signaling pathway genes for blood pressure, folate and cholesterol levels among hypertensives : an epistasis analysis

Wei, Keat, Menon, Saras, Griffiths, Lyn R., & Gan, Siew Hua (2014) Signaling pathway genes for blood pressure, folate and cholesterol levels among hypertensives : an epistasis analysis. Journal of Human Hypertension, 29, pp. 99-104.

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Irregular atrial pressure, defective folate and cholesterol metabolism contribute to the pathogenesis of hypertension. However, little is known about the combined roles of the methylenetetrahydrofolate reductase (MTHFR), apolipoprotein-E (ApoE) and angiotensin-converting enzyme (ACE) genes, which are involved in metabolism and homeostasis. The objective of this study is to investigate the association of the MTHFR 677 C>T and 1298A>C, ACE insertion–deletion (I/D) and ApoE genetic polymorphisms with hypertension and to further explore the epistasis interactions that are involved in these mechanisms. A total of 594 subjects, including 348 normotensive and 246 hypertensive ischemic stroke subjects were recruited. The MTHFR 677 C>T and 1298A>C, ACE I/D and ApoEpolymorphisms were genotyped and the epistasis interaction were analyzed. The MTHFR 677 C>T and ApoE polymorphisms demonstrated significant associations with susceptibility to hypertension in multiple logistic regression models, multifactor dimensionality reduction and a classification and regression tree. In addition, the logistic regression model demonstrated that significant interactions between the ApoE E3E3, E2E4, E2E2 and MTHFR 677 C>T polymorphisms existed. In conclusion, the results of this epistasis study indicated significant association between the ApoE and MTHFR polymorphisms and hypertension.

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6 citations in Scopus
4 citations in Web of Science®
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ID Code: 79633
Item Type: Journal Article
Refereed: Yes
DOI: 10.1038/jhh.2014.53
ISSN: 1476-5527
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Macmillan Publishers Limited
Deposited On: 23 Dec 2014 04:18
Last Modified: 23 Jun 2017 14:01

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