A numerical method for the fractional Fitzhugh–Nagumo monodomain model
Liu, Fawang, Turner, Ian, Anh, Vo, Yang, Qianqian, & Burrage, Kevin (2012) A numerical method for the fractional Fitzhugh–Nagumo monodomain model. The ANZIAM Journal, 54(supp), p.C608-C629.
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A fractional FitzHugh–Nagumo monodomain model with zero Dirichlet boundary conditions is presented, generalising the standard monodomain model that describes the propagation of the electrical potential in heterogeneous cardiac tissue. The model consists of a coupled fractional Riesz space nonlinear reaction-diffusion model and a system of ordinary differential equations, describing the ionic fluxes as a function of the membrane potential. We solve this model by decoupling the space-fractional partial differential equation and the system of ordinary differential equations at each time step. Thus, this means treating the fractional Riesz space nonlinear reaction-diffusion model as if the nonlinear source term is only locally Lipschitz. The fractional Riesz space nonlinear reaction-diffusion model is solved using an implicit numerical method with the shifted Grunwald–Letnikov approximation, and the stability and convergence are discussed in detail in the context of the local Lipschitz property. Some numerical examples are given to show the consistency of our computational approach.
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|Item Type:||Journal Article|
|Keywords:||fractional FitzHugh--Nagumo Monodomain Model;fractional Riesz space nonlinear reaction-diffusion model; stability and convergence|
|Subjects:||Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > OTHER MATHEMATICAL SCIENCES (019900)|
|Divisions:||Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Deposited On:||06 Jan 2015 03:18|
|Last Modified:||04 Feb 2015 17:17|
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