Molecular profiling of exudate from chronic ulcerated wounds

Broszczak, Daniel Aaron (2015) Molecular profiling of exudate from chronic ulcerated wounds. PhD thesis, Queensland University of Technology.

[img] Daniel Broszczak Thesis (PDF 23MB)
Administrators only until 16 December 2016

Abstract

Non-healing wounds represent a significant burden to healthcare systems and societies worldwide. Current best practice treatments of chronic wounds can require patients to undergo extensive periods of therapy without any positive outcome. This consumes substantial healthcare resources and severely impacts patient quality of life. At present, there are no measures to predict a patient's response to best practice care. The hypothesis of this thesis was that biochemical markers could be found within the wound fluid of chronic ulcers and these markers could predict the healing outcome of an ulcer undergoing best practice care. Discovery phase proteomic and mass spectrometry techniques were utilised to determine novel proteins that correlated with the healing outcome of ulcers. These candidate biomarkers could be developed into simple dip-stick tools for use in clinical practice. This would aid clinicians in the choice of effective wound management strategies to address hard-to-heal wounds.

Impact and interest:

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ID Code: 79907
Item Type: QUT Thesis (PhD)
Supervisor: Parker, Tony, Upton, Zee, & Shooter, Gary
Additional Information: An embargo has been granted until 16 Dec 2016.
Keywords: Proteomics, Chronic wound, Mass spectrometry, Diagnostic, Biomarker, Bacteria, SWATH-MS, Protein profiling, Gene ontology, Ulcer
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 26 Feb 2015 05:06
Last Modified: 08 Sep 2015 06:43

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