Deformation of a three-dimensional red blood cell in a stenosed micro-capillary

Polwaththe-Gallage, Hasitha-Nayanajith, Saha, Suvash C., & Gu, YuanTong (2014) Deformation of a three-dimensional red blood cell in a stenosed micro-capillary. In 8th Australasian Congress on Applied Mechanics (ACAM 8), 23-26 November 2014, Melbourne, Australia.

Abstract

Red blood cells (RBCs) exhibit different types of motions and deformations when the blood flows through capillaries. Interestingly, due to the complex three-dimensional structure of the RBC membrane, RBCs show three-dimensional motions and deformations in the blood flow. These motions and deformations of the RBCs highly depend on the stiffness of the RBC membrane and on the geometrical parameters of the capillary through which blood flows. However, capillaries always do not have uniform cross sections and some capillaries have stenosed segments, where cross sectional area suddenly reduces. Further, some diseases can alter the stiffness of the RBC membrane drastically. In this study, the deformation behaviour of a single three-dimensional RBC is examined, when it moves through a stenosed capillary. A three-dimensional spring network is used to model the RBC membrane. The RBC’s inside and outside fluids are discretized into a finite number of mass points and treated by smoothed particle hydrodynamics (SPH) method. The capillary is considered as a rigid tube with a stenosed section. The deformation index, mean velocity and total energy of the RBC are analysed when it flows through the stenosed capillary. Further, motion and deformation of the RBCs with different membrane stiffness (KB) are compared when they flow through the stenosed segment of the capillary. The simulation results demonstrate the RBCs are subjected to a larger deformation when they move through the stenosed part of the capillary and the RBCs with lower KBvalues easily pass through the stenosed segment of the capillary. Further, RBCs having higher KBvalues have a lower mean velocity and it leads to slow down the overall blood flow rate

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ID Code: 80029
Item Type: Conference Paper
Refereed: Yes
Additional URLs:
Keywords: Meshfree Methods, Microcirculation, Numerical Simulations, Red Blood Cell (RBC), Smoothed Particle Hydrodynamics (SPH), Stenosed Capillary, Three-dimensional (3-d)
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Funding:
Copyright Owner: Copyright 2014 [please consult the authors]
Deposited On: 14 Jan 2015 23:05
Last Modified: 17 Jan 2015 01:20

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