Pathogenesis of Fallopian tube damage caused by Chlamydia trachomatis infections

Hafner, Louise M. (2015) Pathogenesis of Fallopian tube damage caused by Chlamydia trachomatis infections. Contraception, 92(2), pp. 108-115.

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Abstract

Chlamydia trachomatis is the leading cause of bacterial sexually transmitted disease worldwide resulting in 4–5 million new cases of Chlamydia annually and an estimated 100 million cases per annum. Infections of the lower female genital tract (FGT) frequently are asymptomatic so they often remain undiagnosed or untreated. If infections are either not resolved, or are left untreated, chlamydia can ascend to the upper FGT and infect the fallopian tubes (FTs) causing salpingitis that may lead to functional damage of the FTs and tubal factor infertility (TFI).

Clinical observations and experimental data have indicated a role for antibodies against C. trachomatis proteins such as the 60 kDa heat-shock protein 60 (cHSP60) in the immunopathogenesis of TFI. When released from infected cells cHSP60 can induce pro-inflammatory immune responses that may functionally impair the FTs leading to fibrosis and luminal occlusion.

Chlamydial pathogenesis of irreversible and permanent tubal damage is a consequence of innate and adaptive host immune responses to ongoing or repeated infections. The extracellular matrix (ECM) that is regulated by metalloproteinases (MMPs) may also be modified by chlamydial infections of the FGT. This review will highlight protective and pathogenic immune responses to ongoing and repeated chlamydial infections of the FGT. It will also present two recent hypotheses to explain mechanisms that may contribute to FT damage during a C. trachomatis infection. If Chlamydia immunopathology can be controlled it might yield a method of inducing fibrosis and thus provide a means of non-surgical permanent contraception for women.

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3 citations in Scopus
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3 citations in Web of Science®

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ID Code: 80076
Item Type: Journal Article
Refereed: Yes
Keywords: Chlamydia trachomatis, Fallopian tube damage, Immunopathogenesis
DOI: 10.1016/j.contraception.2015.01.004
ISSN: 0010-7824
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 Published by Elsevier Inc.
Copyright Statement: Licensed under the Creative Commons Attribution; Non-Commercial; No-Derivatives 4.0 International. DOI: : 10.1016/j.contraception.2015.01.004
Deposited On: 15 Jan 2015 00:44
Last Modified: 06 Sep 2016 13:16

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