Executive functioning of 4 children with hyperphenylalaninemia from childhood to adolescence
Sharman, Rachael R., Sullivan, Karen A., Jones, Toni, Young, Ross McD., & McGill, Jim (2015) Executive functioning of 4 children with hyperphenylalaninemia from childhood to adolescence. Pediatrics, 135(4), e1072-e1074.
Hyperphenylalaninemia is a variant of phenylketonuria, and debate remains as to what, if any, active management of this condition is required to preserve cognitive function and psychological well-being. This study is the first to examine longitudinally the executive function (EF) in adolescents with hyperphenylalaninemia. Two sibling pairs with mild hyperphenylalaninemia underwent neuropsychological examination in early childhood and again in adolescence using EF tests that were highly sensitive to phenylalanine exposure. By early adolescence, none of the 4 children demonstrated EF impairment. The children demonstrated a typical developmental trajectory of EF from childhood to adolescence, given phenylalanine exposure consistent with their condition.
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|Item Type:||Journal Article|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
|Deposited On:||16 Jan 2015 00:02|
|Last Modified:||02 Feb 2016 04:36|
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