The role of δ-opioid receptors in learning and memory underlying the development of addiction

Klenowski, Paul, Morgan, Michael, & Bartlett, Selena E. (2015) The role of δ-opioid receptors in learning and memory underlying the development of addiction. British Journal of Pharmacology, 172(2), pp. 297-310.

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Abstract

Opioids are important endogenous ligands that exist in both invertebrates and vertebrates and signal by activation of opioid receptors to produce analgesia and reward or pleasure. The μ-opioid receptor is the best known of the opioid receptors and mediates the acute analgesic effects of opiates, while the δ-opioid receptor (DOR) has been less well studied and has been linked to effects that follow from chronic use of opiates such as stress, inflammation and anxiety. Recently, DORs have been shown to play an essential role in emotions and increasing evidence points to a role in learning actions and outcomes. The process of learning and memory in addiction has been proposed to involve strengthening of specific brain circuits when a drug is paired with a context or environment. The DOR is highly expressed in the hippocampus, amygdala, striatum and other basal ganglia structures known to participate in learning and memory. In this review, we will focus on the role of the DOR and its potential role in learning and memory underlying the development of addiction.

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ID Code: 80177
Item Type: Journal Article
Refereed: Yes
Keywords: δ-opioid receptor, enkephalin, ethanol, learning, memory, reward
DOI: 10.1111/bph.12618
ISSN: 0007-1188
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1999-2014 John Wiley & Sons, Inc.
Deposited On: 16 Jan 2015 04:26
Last Modified: 25 Oct 2016 23:41

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