Estimating the burden of disease attributable to high cholesterol in South Africa in 2000

Norman, Rosana, Bradshaw, Debbie, Steyn, Krisela, & Gaziano, Thomas (2007) Estimating the burden of disease attributable to high cholesterol in South Africa in 2000. South African Medical Journal, 97(8), pp. 708-715.

View at publisher (open access)

Abstract

Objectives

To estimate the burden of disease attributable to high cholesterol in adults aged 30 years and older in South Africa in 2000.

Design

World Health Organization comparative risk assessment (CRA) methodology was followed. Small community studies were used to derive the prevalence by population group. Population-attributable fractions were calculated and applied to revised burden of disease estimates for the relevant disease categories for each population group. The total attributable burden for South Africa in 2000 was obtained by adding the burden attributed to high cholesterol for the four population groups. Monte Carlo simulation-modelling techniques were used for uncertainty analysis.

Setting

South Africa.

Subjects

Black African, coloured, white and Indian adults aged 30 years and older.

Outcome measures

Mortality and disability-adjusted life years (DALYs) from ischaemic heart disease (IHD) and ischaemic stroke.

Results

Overall, about 59% of IHD and 29% of ischaemic stroke burden in adult males and females (30+ years) were attributable to high cholesterol (≥ 3.8 mmol/l), with marked variation by population group. High cholesterol was estimated to have caused 24 144 deaths (95% uncertainty interval 22 404 - 25 286) or 4.6% (95% uncertainty interval 4.3 - 4.9%) of all deaths in South Africa in 2000. Since most cholesterol-related cardiovascular disease events occurred in middle or old age, the loss of life years comprised a smaller proportion of the total: 222 923 DALYs (95% uncertainty interval 206 712 - 233 460) or 1.4% of all DALYs (95% uncertainty interval 1.3 - 1.4%) in South Africa in 2000.

Conclusions

High cholesterol is an important cardiovascular risk factor in all population groups in South Africa.

Impact and interest:

32 citations in Scopus
Search Google Scholar™
23 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

19 since deposited on 27 Jan 2015
6 in the past twelve months

Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 80244
Item Type: Journal Article
Refereed: Yes
Additional Information: Research with the South African Comparative Risk Assessment
Collaborating Group
Keywords: South Africa, burden of disease, high cholesterol, attributable burden
ISSN: 2078-5135
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Epidemiology (111706)
Australian and New Zealand Standard Research Classification
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
Copyright Owner: Copyright 2007 South African Medical Journal
Deposited On: 27 Jan 2015 01:30
Last Modified: 09 Feb 2015 01:52

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page