Conformational Spread as a Mechanism for Cooperativity in the Bacterial Flagellar Switch
Bai, F., Branch, R. W., Nicolau, D. V., Pilizota, T., Steel, B. C., Maini, P. K., & Berry, R. M. (2010) Conformational Spread as a Mechanism for Cooperativity in the Bacterial Flagellar Switch. Science, 327(5966), pp. 685-689.
The bacterial flagellar switch that controls the direction of flagellar rotation during Chemotaxis has a highly cooperative response. This has previously been understood in terms of the classic two-state, concerted model of allosteric regulation. Here, we used high-resolution optical microscopy to observe switching of single motors and uncover the stochastic multistate nature of the switch. Our observations are in detailed quantitative agreement with a recent general model of allosteric cooperativity that exhibits conformational spread-the stochastic growth and shrinkage of domains of adjacent subunits sharing a particular conformational state. We expect that conformational spread will be important in explaining cooperativity in other large signaling complexes.
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|Item Type:||Journal Article|
|Divisions:||Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Deposited On:||19 Jan 2015 06:05|
|Last Modified:||20 Jan 2015 03:33|
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