Conformational Spread as a Mechanism for Cooperativity in the Bacterial Flagellar Switch

Bai, F., Branch, R. W., Nicolau, D. V., Pilizota, T., Steel, B. C., Maini, P. K., & Berry, R. M. (2010) Conformational Spread as a Mechanism for Cooperativity in the Bacterial Flagellar Switch. Science, 327(5966), pp. 685-689.

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The bacterial flagellar switch that controls the direction of flagellar rotation during Chemotaxis has a highly cooperative response. This has previously been understood in terms of the classic two-state, concerted model of allosteric regulation. Here, we used high-resolution optical microscopy to observe switching of single motors and uncover the stochastic multistate nature of the switch. Our observations are in detailed quantitative agreement with a recent general model of allosteric cooperativity that exhibits conformational spread-the stochastic growth and shrinkage of domains of adjacent subunits sharing a particular conformational state. We expect that conformational spread will be important in explaining cooperativity in other large signaling complexes.

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ID Code: 80287
Item Type: Journal Article
Refereed: Yes
DOI: 10.1126/science.1182105
ISSN: 1095-9203
Divisions: Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 19 Jan 2015 06:05
Last Modified: 20 Jan 2015 03:33

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