Protein Molecular Surface Mapped at Different Geometrical Resolutions

Fraternali, Franca, Nicolau, Dan V., Paszek, Ewa, Fulga, Florin, & Nicolau, Dan V. (2013) Protein Molecular Surface Mapped at Different Geometrical Resolutions. PLoS ONE, 8(3), e58896-e58896.

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Many areas of biochemistry and molecular biology, both fundamental and applications-orientated, require an accurate construction, representation and understanding of the protein molecular surface and its interaction with other, usually small, molecules. There are however many situations when the protein molecular surface gets in physical contact with larger objects, either biological, such as membranes, or artificial, such as nanoparticles. The contribution presents a methodology for describing and quantifying the molecular properties of proteins, by geometrical and physico-chemical mapping of the molecular surfaces, with several analytical relationships being proposed for molecular surface properties. The relevance of the molecular surface-derived properties has been demonstrated through the calculation of the statistical strength of the prediction of protein adsorption. It is expected that the extension of this methodology to other phenomena involving proteins near solid surfaces, in particular the protein interaction with nanoparticles, will result in important benefits in the understanding and design of protein-specific solid surfaces. © 2013 Nicolau et al.

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ID Code: 80293
Item Type: Journal Article
Refereed: Yes
DOI: 10.1371/journal.pone.0058896
ISSN: 1932-6203
Divisions: Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: The authors
Deposited On: 19 Jan 2015 05:01
Last Modified: 20 Jan 2015 02:58

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