Single-cell force spectroscopy, an emerging tool to quantify cell adhesion to biomaterials

Taubenberger, Anna, Hutmacher, Dietmar, & Muller, Daniel (2014) Single-cell force spectroscopy, an emerging tool to quantify cell adhesion to biomaterials. Tissue Engineering Part B: Reviews, 20(1), pp. 40-55.

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Abstract

Cell adhesion receptors play a central role in sensing and integrating signals provided by the cellular environment. Thus, understanding adhesive interactions at the cell-biomaterial interface is essential to improve the design of implants that should emulate certain characteristics of the cell's natural environment. Numerous cell adhesion assays have been developed; among these, atomic force microscopy-based single-cell force spectroscopy (AFM-SCFS) provides a versatile tool to quantify cell adhesion at physiological conditions. Here we discuss how AFM-SCFS can be used to quantify the adhesion of living cells to biomaterials and give examples of using AFM-SCFS in tissue engineering and regenerative medicine. We anticipate that in the near future, AFM-SCFS will be established in the biomaterial field as an important technique to quantify cell-biomaterial interactions and thereby will contribute to the optimization of implants, scaffolds, and medical devices.

Impact and interest:

19 citations in Scopus
17 citations in Web of Science®
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ID Code: 80387
Item Type: Journal Article
Refereed: Yes
Keywords: Cell adhesion & migration; Biomedical materials; Tissue engineering;, Spectrum analysis, Biocompatible Materials;
DOI: 10.1089/ten.teb.2013.0125
ISSN: 1937-3368
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MATERIALS ENGINEERING (091200)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Funding:
Deposited On: 21 Jan 2015 22:48
Last Modified: 02 Sep 2016 03:20

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