Functional MRI BOLD response to Tower of London performance of first-episode schizophrenia patients using cortical pattern matching

Rasser, Paul E., Johnston, Patrick, Lagopoulos, Jim, Ward, Philip B., Schall, Ulrich, Thienel, Renate, Bender, Stefan, Toga, Arthur W., & Thompson, Paul M. (2005) Functional MRI BOLD response to Tower of London performance of first-episode schizophrenia patients using cortical pattern matching. NeuroImage, 26(3), pp. 941-951.

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Due to its three-dimensional folding pattern, the human neocortex; poses a challenge for accurate co-registration of grouped functional; brain imaging data. The present study addressed this problem by; employing three-dimensional continuum-mechanical image-warping; techniques to derive average anatomical representations for coregistration; of functional magnetic resonance brain imaging data; obtained from 10 male first-episode schizophrenia patients and 10 age-matched; male healthy volunteers while they performed a version of the; Tower of London task. This novel technique produced an equivalent; representation of blood oxygenation level dependent (BOLD) response; across hemispheres, cortical regions, and groups, respectively, when; compared to intensity average co-registration, using a deformable; Brodmann area atlas as anatomical reference. Somewhat closer; association of Brodmann area boundaries with primary visual and; auditory areas was evident using the gyral pattern average model.; Statistically-thresholded BOLD cluster data confirmed predominantly; bilateral prefrontal and parietal, right frontal and dorsolateral; prefrontal, and left occipital activation in healthy subjects, while; patients’ hemispheric dominance pattern was diminished or reversed,; particularly decreasing cortical BOLD response with increasing task; difficulty in the right superior temporal gyrus. Reduced regional gray; matter thickness correlated with reduced left-hemispheric prefrontal/; frontal and bilateral parietal BOLD activation in patients. This is the; first study demonstrating that reduction of regional gray matter in; first-episode schizophrenia patients is associated with impaired brain; function when performing the Tower of London task, and supports; previous findings of impaired executive attention and working memory; in schizophrenia.

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ID Code: 80845
Item Type: Journal Article
Refereed: Yes
Keywords: structural magnetic resonance imaging, functional magnetic resonance imaging, cortex, deformable Brodmann area atlas, three-dimensional continuun-mechanical image-warping, cortical pattern matching, first-episode schizophrenia, Tower of London, planning, executive attention, working memory
DOI: 10.1016/j.neuroimage.2004.11.054
ISSN: 1053-8119
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Psychiatry (incl. Psychotherapy) (110319)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Biological Psychology (Neuropsychology Psychopharmacology Physiological Psychology) (170101)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
Deposited On: 27 Jan 2015 23:16
Last Modified: 09 Feb 2015 05:43

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