Functional neuroanatomy of auditory mismatch processing : an event-related fMRI study of duration-deviant oddballs

Schall, Ulrich, Johnston, Patrick, Todd, Juanita, Ward, Philip B., & Michie, Patricia T. (2003) Functional neuroanatomy of auditory mismatch processing : an event-related fMRI study of duration-deviant oddballs. NeuroImage, 20(2), pp. 729-736.

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Abstract

This study was designed to identify the neural networks underlying automatic auditory deviance detection in 10 healthy subjects using functional magnetic resonance imaging. We measured blood oxygenation level-dependent contrasts derived from the comparison of blocks of stimuli presented as a series of standard tones (50 ms duration) alone versus blocks that contained rare duration-deviant tones (100 ms) that were interspersed among a series of frequent standard tones while subjects were watching a silent movie. Possible effects of scanner noise were assessed by a “no tone” condition. In line with previous positron emission tomography and EEG source modeling studies, we found temporal lobe and prefrontal cortical activation that was associated with auditory duration mismatch processing. Data were also analyzed employing an event-related hemodynamic response model, which confirmed activation in response to duration-deviant tones bilaterally in the superior temporal gyrus and prefrontally in the right inferior and middle frontal gyri. In line with previous electrophysiological reports, mismatch activation of these brain regions was significantly correlated with age. These findings suggest a close relationship of the event-related hemodynamic response pattern with the corresponding electrophysiological activity underlying the event-related “mismatch negativity” potential, a putative measure of auditory sensory memory.

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ID Code: 80871
Item Type: Journal Article
Refereed: Yes
Keywords: auditory information processing, mismatch negativity (MMN), auditory sensory memory, event-related functional magnetic resonance imaging, temporal lobes, frontal lobes, prefrontal cortex, schizophrenia, dyslexia
DOI: 10.1016/S1053-8119(03)00398-7
ISSN: 1053-8119
Subjects: Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Biological Psychology (Neuropsychology Psychopharmacology Physiological Psychology) (170101)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Sensory Processes Perception and Performance (170112)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
Deposited On: 27 Jan 2015 23:07
Last Modified: 27 Jan 2015 23:07

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