The effect of the lipid layer on tear film behaviour

McElwain, D. L. S., Jones, M. B., Fulford, G., Collins, M. J., & Roberts, A. P. (2006) The effect of the lipid layer on tear film behaviour. Bulletin of Mathematical Biology, 68(6), pp. 1355-1381.

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This paper investigates the effect of surfactants during tear film deposition and subsequent thinning. The surfactants occur naturally on the surface of the tear film in the form of a lipid layer. A lubrication model is developed that describes lipid spreading and film height evolution. It is shown that lipids may play an important role in drawing the tear film up the cornea during the opening phase of the blink. Further, nonuniform distributions of lipids may lead to a rapid thinning of the tear film behind the advancing lipid front (shock). Experiments using a fluorescein dye technique and using a tearscope were undertaken in order to visualise the motion of the lipid layer and any associated shocks immediately after a blink. It is found that the lipid layer continues to spread upwards on the cornea after the opening phase of the blink, in agreement with the model. Using the experimental data, lipid particles were tracked in order to determine the surface velocity and these results are compared to the model predictions.

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25 citations in Web of Science®

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ID Code: 8099
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author.
DOI: 10.1007/s11538-006-9105-9
ISSN: 0092-8240
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)
Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > PURE MATHEMATICS (010100) > Pure Mathematics not elsewhere classified (010199)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > Mathematical Sciences
Current > Schools > School of Optometry & Vision Science
Past > Schools > School of Physical & Chemical Sciences
Copyright Owner: Copyright 2006 Springer
Deposited On: 19 Jun 2007 00:00
Last Modified: 24 Mar 2015 02:17

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