Large Scale Simulations of Hippocampal-Neocortical Interactions in a Parallel Version of Genesis

Klopp, John, Johnston, Patrick, Nenov, Valeriy, Goddard, Nigel, Hood, Greg, & Halgren, Eric (1998) Large Scale Simulations of Hippocampal-Neocortical Interactions in a Parallel Version of Genesis. In Bower, James M. (Ed.) Computational Neuroscience : Trends in Research, 1998. Plenum Press, New York, pp. 59-64.

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A hippocampal-CA3 memory model was constructed with PGENESIS, a recently developed version of GENESIS that allows for distributed processing of a neural network simulation. A number of neural models of the human memory system have identified the CA3 region of the hippocampus as storing the declarative memory trace. However, computational models designed to assess the viability of the putative mechanisms of storage and retrieval have generally been too abstract to allow comparison with empirical data. Recent experimental evidence has shown that selective knock-out of NMDA receptors in the CA1 of mice leads to reduced stability of firing specificity in place cells. Here a similar reduction of stability of input specificity is demonstrated in a biologically plausible neural network model of the CA3 region, under conditions of Hebbian synaptic plasticity versus an absence of plasticity.

The CA3 region is also commonly associated with seizure activity. Further simulations of the same model tested the response to continuously repeating versus randomized nonrepeating input patterns. Each paradigm delivered input of equal intensity and duration. Non-repeating input patterns elicited a greater pyramidal cell spike count. This suggests that repetitive versus non-repeating neocortical inpus has a quantitatively different effect on the hippocampus. This may be relevant to the production of independent epileptogenic zones and the process of encoding new memories.

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ID Code: 81276
Item Type: Book Chapter
DOI: 10.1007/978-1-4615-4831-7_10
ISBN: 9781461548317
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
Deposited On: 29 Jan 2015 00:05
Last Modified: 29 Oct 2015 16:49

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