DNA molecules and human therapeutics

Danquah, Michael K., Ho, Jenny, Liu, Shan, & Forde, Gareth M. (2009) DNA molecules and human therapeutics. African Journal of Biotechnology, 8(25), pp. 7190-7195.

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Abstract

Nucleic acid molecules are championing a new generation of reverse engineered biopharmaceuticals. In terms of potential application in gene medicine, plasmid DNA (pDNA) vectors have exceptional therapeutic and immunological profiles as they are free from safety concerns associated with viral vectors, display non-toxicity and are simpler to develop. This review addresses the potential applications of pDNA molecules in vaccine design/development and gene therapy via recombinant DNA technology as well as a staged delivery mechanism for the introduction of plasmid-borne gene to target cells via the nasal route.

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ID Code: 81542
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Gene therapy, Plasmid DNA, Staged delivery nasal route, Vaccine development, beta lactam antibiotic, cancer vaccine, DNA, DNA vaccine, glycoprotein E2, kanamycin, naked DNA, plasmid vector, polymer, virus vector, acquired immune deficiency syndrome, bioengineering, cellular immunity, drug delivery system, gene vector, human, humoral immunity, intranasal drug administration, malaria, nonhuman, nonviral gene therapy, plasmid, recombinant DNA technology, review, RNA interference
ISSN: 1684-5315
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2009 Academic Journals
Copyright Statement: All articles published by Academic Journals are licensed under the Creative Commons Attribution 4.0 International License. This permits anyone to copy, redistribute, remix, transmit and adapt the work provided the original work and source is appropriately cited.
Deposited On: 05 Feb 2015 23:53
Last Modified: 11 Feb 2015 03:17

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