Identification and characterization of novel proteolytic interactions of prostate cancer-expressed kallikrein-related peptidases, type II transmembrane serine proteases and matrix metalloproteinases
Reid, Janet C. (2015) Identification and characterization of novel proteolytic interactions of prostate cancer-expressed kallikrein-related peptidases, type II transmembrane serine proteases and matrix metalloproteinases. PhD thesis, Queensland University of Technology.
This study investigated interactions of protein-cleaving enzymes (or proteases) that promote prostate cancer progression. It provides the first evidence of a novel regulatory network of protease activity at the surface of cells. The proteases kallikrein-related peptidases 4 and 14, and matrix metalloproteinases 3 and 9 are cleaved at the cell surface by the cell surface proteases hepsin and TMPRSS2. These cleavage events potentially regulate activation of downstream targets of kallikrein 4 and 14 such as cell surface signalling via the protease-activated receptors (PARs) and cell growth-promoting factors such as hepatocyte-growth factor.
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|Item Type:||QUT Thesis (PhD)|
|Supervisor:||Hooper, John & Clements, Judith|
|Keywords:||Kallikrein-Related Peptidase (KLK), Type II Transmembrane Serine Protease (TTSP), Matrix Metalloproteinase (MMP), Protease-Activated Receptor (PAR), Hepatocyte Growth Factor Activator Inhibitor-1, Hepatocyte Growth Factor (HGF), Calcium Signalling, Activity Based Probe (ABP), Cell Surface, Proteolytic Cascade|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Institution:||Queensland University of Technology|
|Deposited On:||26 Feb 2015 06:53|
|Last Modified:||08 Sep 2015 06:37|
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