Potential role of bioactive lipids in the development of non-antibody mediated transfusion-related acute lung injury (TRALI)

Tung, John-Paul, Meka, Denisa, Sultana, Annette J, Gabriela, Simonova, Christensen, Anne-Marie, Flower, Robert L., & Dean, Melinda M (2014) Potential role of bioactive lipids in the development of non-antibody mediated transfusion-related acute lung injury (TRALI). In American Society of Hematology, 4-9 December 2014, San Fransisco, USA.

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Abstract

Transfusion-related acute lung injury (TRALI) has been the leading cause of transfusion-related morbidity and mortality in the UK and the USA in recent years. A threshold mechanism of TRALI has been proposed in which both patient factors (type and/or severity of clinical insult) and blood product factors (strength and/or concentration of antibodies or biological response modifiers) interact to surpass a threshold for TRALI development (Bux et al. Br J Haematol; 2007; 136: 788-99). The risk of developing antibody-mediated TRALI has been minimised by the introduction of risk-reduction strategies such as limiting the use of plasma from female donors. In contrast, there are no strategies currently in place to mitigate the development of non-antibody mediated TRALI as the mechanisms remain largely undefined. Previous studies have implicated non-polar lipids such as arachidonic acid and various species of hydroxyeicosatetranoic acid (HETE) in the development of non-antibody mediated TRALI (Silliman et al. Transfusion; 2011; 51: 2549-54), however the contribution of these lipids to the development of an inflammatory response in TRALI is poorly understood.

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ID Code: 81810
Item Type: Conference Item (Poster)
Refereed: Yes
Additional Information: Blood 2014; 124(21):4285
Keywords: Non-antibody mediated TRALI, Bioactive lipids, Inflammatory response
ISSN: 0006-4971
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2014 The American Society of Hematology
Deposited On: 15 Feb 2015 23:13
Last Modified: 15 Feb 2015 23:14

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