Mathematical models of calcium and tight junctions in normal and reconstructed epidermis

Adams, Matthew P. (2015) Mathematical models of calcium and tight junctions in normal and reconstructed epidermis. PhD by Publication, Queensland University of Technology.


This project investigated the calcium distributions of the skin, and the growth patterns of skin substitutes grown in the laboratory, using mathematical models. The research found that the calcium distribution in the upper layer of the skin is controlled by three different mechanisms, not one as previously thought. The research also suggests that tight junctions, which are adhesions between neighbouring skin cells, cannot be solely responsible for the differences in the growth patterns of skin substitutes and normal skin.

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177 since deposited on 13 Mar 2015
107 in the past twelve months

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ID Code: 81869
Item Type: QUT Thesis (PhD by Publication)
Supervisor: Mallet, Dann & Pettet, Graeme
Keywords: calcium gradient, continuum, epidermis, growing domain, mathematical biology, nonuniform growth, porous medium, reconstructed epidermis, skin substitute, tight junctions
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 13 Mar 2015 05:18
Last Modified: 24 Oct 2015 05:06

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