Environments for zonal cartilage tissue engineering

Kuaha, Kunnika (2015) Environments for zonal cartilage tissue engineering. PhD thesis, Queensland University of Technology.


Articular cartilage is a highly organized tissue with cellular and matrix properties that vary with depth zones. Regenerating this zonal organization has proven difficult in tissue-engineered cartilage to treat damaged cartilage. In this thesis, we evaluated the effects of culture environments that mimic aspects of the native cartilage environment on chondrocyte subpopulations. We found that decellularized cartilage matrix can improve zonal tissue-engineered cartilage. Also, chondrocytes respond to signals from bone cells and compressive stimulation in a zone-dependent manner. These results highlight the importance of a zone-specific environment to improve tissue-engineered cartilage in vitro.

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80 since deposited on 12 Mar 2015
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ID Code: 81992
Item Type: QUT Thesis (PhD)
Supervisor: Klein, Travis & Hutmacher, Dietmar
Keywords: Decellularized ECM, Cartilage tissue engineering, Chondrocyte subpopulations, Cartilage extracellular matrix (ECM), Zonal constructs, Osteoarthritis (OA), Environments for zonal cartilage tissue engineerin
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 12 Mar 2015 05:22
Last Modified: 08 Sep 2015 06:30

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