Autologous human kidney proximal tubule epithelial cells (PTEC) modulate dendritic cell (DC), T cell and B cell responses

Sampangi, Sandeep (2015) Autologous human kidney proximal tubule epithelial cells (PTEC) modulate dendritic cell (DC), T cell and B cell responses. PhD thesis, Queensland University of Technology.


This is a comprehensive study of human kidney proximal tubular epithelial cells (PTEC) which are known to respond to and mediate the pathological process of a range of kidney diseases. It identifies various molecules expressed by PTEC and how these molecules participate in down-regulating the inflammatory process, thereby highlighting the clinical potential of these molecules to treat various kidney diseases. In the disease state, PTEC gain the ability to regulate the immune cell responses present within the interstitium. This down-regulation is a complex interaction of contact dependent/independent mechanisms involving various immuno-regulatory molecules including PD-L1, sHLA-G and IDO. The overall outcome of this down-regulation is suppressed DC maturation, decreased number of antibody producing B cells and low T cell responses. These manifestations within a clinical setting are expected to dampen the ongoing inflammation, preventing the damage caused to the kidney tissue.

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1 citations in Web of Science®
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ID Code: 82033
Item Type: QUT Thesis (PhD)
Supervisor: Wilkinson, Ray, Klein, Travis, & Beagley, Kenneth
Keywords: Autologous proximal tubule epithelial cells, Dendritic cells, T cells, B cells, Indoleamine-2,3-dioxygenase (IDO), Programmed cell death ligand-1 (PD-L1), Soluble human leukocyte antigen-G (sHLA-G)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 13 Mar 2015 03:18
Last Modified: 13 Mar 2015 03:18

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