Cross-scale biophysics modelling of F-actin cytoskeleton in cell

Li, Tong (2015) Cross-scale biophysics modelling of F-actin cytoskeleton in cell. PhD by Publication, Queensland University of Technology.


This thesis is a comparative study of the modelling of mechanical behaviours of F-actin cytoskeleton which is an important structural component in living cells. A new granular model was developed for F-actin cytoskeleton based on the concept of multiscale modelling. This framework overcomes difficulties encountered in physical modelling of cytoskeleton in conventional continuum mechanics modelling, and the computational challenges in all-atom molecular dynamics simulation. The thermostat algorithm was further modified to better predict the thermodynamic properties of F-actin cytoskeleton in modelling. This multiscale modelling framework was applied in explaining the physical mechanisms of cytoskeleton responses to external mechanical loads.

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25 since deposited on 15 Apr 2015
14 in the past twelve months

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ID Code: 82293
Item Type: QUT Thesis (PhD by Publication)
Supervisor: Gu, YuanTong, Oloyede, Kunle, & Yarlagadda, Prasad
Keywords: F-actin cytoskeleton, Molecular dynamics, Mechanobiology, Biophysics, Numerical modelling
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 15 Apr 2015 02:42
Last Modified: 08 Sep 2015 06:24

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