Comprehensive contribution of filament thickness and crosslinker failure to the rheological property of F-actin cytoskeleton
Li, Tong, Liu, Ling, Hu, Dean, Oloyede, Adekunle, Xiao, Yin, Yarlagadda, Prasad K., & Gu, YuanTong (2015) Comprehensive contribution of filament thickness and crosslinker failure to the rheological property of F-actin cytoskeleton. Cellular and Molecular Bioengineering, 8(2), pp. 278-284.
Rheological property of F-actin cytoskeleton is significant to the restructuring of cytoskeleton under a variety of cell activities. This study numerically validates the rheological property of F-actin cytoskeleton is not only a result of kinetic energy dissipation of F-actin, but also greatly depends on the configuration remodeling of networks structure. Both filament geometry and crosslinker properties can affect the remodeling of F-actin cytoskeleton. The crosslinker unbinding is found to dissipate energy and induce prominent stress relaxation in the F-actin adjacent to cross-linkages. Coupled with F-actin elasticity, the energy dissipation and stress relaxation are more significant in bundled F-actin networks than in single F-actin networks.
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|Item Type:||Journal Article|
|Keywords:||F-actin networks, Crosslinker, Energy Dissipation, Mechanics|
|Subjects:||Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2015 Springer|
|Deposited On:||08 Mar 2015 22:52|
|Last Modified:||02 Jul 2016 21:44|
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