Age-related changes to adenosine in rat coronary resistance vessels
Rose'Meyer, Roselyn, Harden, Fiona, Varela, Jose, & Willis, Roger (1999) Age-related changes to adenosine in rat coronary resistance vessels. General Pharmacology : The Vascular System, 32(1), pp. 35-40.
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The vasodilator effects of adenosine receptor agonists, isoprenaline and histamine were examined in perfused heart preparations from young (4–6 weeks) and mature (12–20 weeks) rats.
Adenosine induced a biphasic concentration-dependent decrease in KCl (35 mM) raised coronary perfusion pressure in hearts from young and mature rats, suggesting the presence of both high- and low-affinity sites for adenosine receptors in the two age groups tested. In heart preparations from mature rats, vasodilator responses to adenosine were significantly reduced compared with responses observed in young rats.
Responses to 5′-N-ethylcarboxamidoadenosine (NECA) and 2-p-(2-carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine hydrochloride (CGS-21680) were reduced in preparations from mature rats, whereas the vasodilator actions of N6-cyclopentyladenosine (CPA) and N6-2-(4-aminophenyl)ethyladenosine (APNEA) did not change with age.
The results presented in this study suggest that several adenosine receptor subtypes mediate vasodilator responses in the coronary circulation of the rat and that a reduction in response to adenosine with age may be due to changes in the high-affinity receptor site.
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|Item Type:||Journal Article|
|Keywords:||Adenosine, receptor, coronary, age, perfused rat heart|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 1999 Elsevier|
|Copyright Statement:||This is the author’s version of a work that was accepted for publication in General Pharmacology : The Vascular System. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in General Pharmacology : The Vascular System, [VOL 32, ISSUE 1, (1999)] DOI: 10.1016/S0306-3623(98)00023-8|
|Deposited On:||08 Mar 2015 23:37|
|Last Modified:||08 Mar 2015 23:37|
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