A biphasic response to adenosine in the coronary vasculature of the K+-arrested perfused rat heart

Harden, Fiona, Harrison, Glenn J., Headrick, John P., Jordon, Lindsay R., & Willis, Roger J. (1996) A biphasic response to adenosine in the coronary vasculature of the K+-arrested perfused rat heart. European Journal of Pharmacology, 307(1), pp. 49-53.

View at publisher


Biphasic vasodilatory responses to adenosine and 5'-N-ethylcarboxamidoadenosine (NECA) were observed in the coronary vasculature of K(+)-arrested perfused rat hearts. Dose-response data for both agonists were best represented by two-site models. For adenosine, two sites with negative log ED50 (pED50) values of 8.1 +/- 0.1 (mean +/- S.E.M) and 5.2 +/- 0.1 were obtained, mediating 31 +/- 2% and 69 +/- 2% of the total response. In the presence of 8-phenyltheophylline, the vasodilatory response to adenosine remained best fitted to a two-site model with pED50 values of 7.0 +/- 0.2 and 5.4 +/- 0.2. The relative contribution of each site to the total response remained unchanged. For NECA, pED50 values of 9.6 +/- 0.1 and 6.8 +/- 0.2 were obtained, representing 48 +/- 3% and 52 +/- 3% of the sites, respectively. In contrast, ATP produced a monophasic response with a pED50 value of 8.8 +/- 0.1. These results provide evidence of adenosine receptor and response heterogeneity in the in situ coronary vasculature.

Impact and interest:

6 citations in Scopus
Search Google Scholar™
3 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 82311
Item Type: Journal Article
Refereed: Yes
Keywords: Adenosine A2A receptor, Adenosine A2B receptor, Adenosine A3 receptor, P3 purinoceptor, Coronary vasculature, Heart, Perfused, Rat
DOI: 10.1016/0014-2999(96)00200-2
ISSN: 0014-2999
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 08 Mar 2015 23:42
Last Modified: 08 Mar 2015 23:42

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page