In vitro microenvironments to study breast cancer bone colonisation

Taubenberger, Anna V. (2014) In vitro microenvironments to study breast cancer bone colonisation. Advanced Drug Delivery Reviews, 79-80, pp. 135-144.

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Bone metastasis occurs frequently in patients with advanced breast cancer and is a major cause of morbidity and mortality in these patients. In order to advance current therapies, the mechanisms leading to the formation of bone metastases and their pathophysiology have to be better understood. Several in vitro models have been developed for systematic studies of interactions between breast cancer cells and the bone microenvironment. Such models can provide insights into the molecular basis of bone metastatic colonisation and also may provide a useful platform to design more physiologically relevant drug testing assays. This review describes different in vitro approaches and discusses their advantages and disadvantages.

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7 citations in Web of Science®

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ID Code: 82582
Item Type: Journal Article
Refereed: Yes
Keywords: in vitro model, breast cancer, bone metastasis, tissue engineering, tumour microenvironment
DOI: 10.1016/j.addr.2014.10.014
ISSN: 0169-409X
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2014 Elsevier
Deposited On: 18 Mar 2015 22:44
Last Modified: 19 Mar 2015 22:25

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