Polybrominated diphenyl ether (PBDE) human half lives estimated from North Americans moving to Australia
Toms, Leisa-Maree Leontjew, Mueller, Jochen F., Sjodin, Andreas, Webster, Thomas F., Jones, Richard, & Harden, Fiona (2014) Polybrominated diphenyl ether (PBDE) human half lives estimated from North Americans moving to Australia. In 14th Annual Workshop on Brominated and Other Flame Retardants, 22-24 June 2014, Indianapolis, Indiana. (Unpublished)
Human half-lives of PentaBDE congeners have been estimated from the decline in serum concentrations measured over a 6-12 month period for a population of exchange students moving from North America to Australia. Australian serum PBDE concentrations are typically between 5 -10 times lower than in North America and we can therefore hypothesize that if the biological half-life is sufficiently short we would observe a decline in serum concentration with length of residence in Australia. Thirty students were recruited over a period of 3 years from whom serum were archived every 2 months during their stay in Australia. Australian residents (n=22) were also sampled longitudinally to estimate general population background levels. All serum samples were analyzed by gas chromatography high resolution mass spectrometry. Key findings confirmed that BDE-47 concentrations in the Australians (median 2.3; <LOD to 11 ng/g lipid) were lower compared to the North Americans (median 9.7; 2 to 91 ng/g lipid). The second finding was that BDE-47 concentrations in the North Americans declined as a result of living in Australia for approximately 6 months (average 22% decrease compared to 4% for the Australians). Estimated BDE-47 half-life ranged from 0.5 – 2.3 years. The presentation will discuss full results and is the first study to provide in vivo estimates of half-life data of PentaBDE congeners.
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|Item Type:||Conference Item (Other)|
|Divisions:||Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||23 Mar 2015 01:53|
|Last Modified:||23 Mar 2015 01:53|
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