Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135kDa cell surface phosphorylated glycoprotein antigen
Hooper, John D., Zijlstra, Andries, Liang, Hongyan, Claassen, Gisela F., Tarin, David, Testa, Jacqueline E., Quigley, James P., & Aimes, Ronald T. (2003) Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135kDa cell surface phosphorylated glycoprotein antigen. Oncogene, 22(12), pp. 1783-1794.
Abstract
We have previously used a subtractive immunization (SI) approach to generate monoclonal antibodies (mAbs) against proteins preferentially expressed by the highly metastatic human epidermoid carcinoma cell line, M+HEp3. Here we report the immunopurication, identication and characterization of SIMA135/CDCP1 (subtractive immunization M+HEp3 associated 135 kDa protein/CUB domain containing protein 1) using one of these mAbs designated 41-2.
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| ID Code: | 8263 |
|---|---|
| Item Type: | Journal Article |
| Additional Information: | For more information, please refer to the journal's website (see hypertext link) or contact the author. Author contact details: jd.hooper@qut.edu.au |
| Keywords: | subtractive immunization, metastasis, SIMA135/CDCP1, proteomics, colon cancer, CUB |
| DOI: | 10.1038/sj.onc.1206220 |
| ISSN: | 0950-9232 |
| Subjects: | Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Science and Technology |
| Copyright Owner: | Copyright 2003 Nature Publishing Group |
| Deposited On: | 26 Jun 2007 |
| Last Modified: | 29 Feb 2012 23:20 |
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