Cell type-dependent, infection-induced, aberrant DNA methylation in gastric cancer

Perrin, Dimitri, Ruskin, Heather J., & Niwa, Tohru (2010) Cell type-dependent, infection-induced, aberrant DNA methylation in gastric cancer. Journal of Theoretical Biology, 264(2), pp. 570-577.

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Abstract

Epigenetic changes correspond to heritable modifications of the chromatin structure, which do not involve any alteration of the DNA sequence but nonetheless affect gene expression. These mechanisms play an important role in cell differentiation, but aberrant occurrences are also associated with a number of diseases, including cancer and neural development disorders.

In particular, aberrant DNA methylation induced by H. Pylori has been found to be a significant risk factor in gastric cancer. To investigate the sensitivity of different genes and cell types to this infection, a computational model of methylation in gastric crypts is developed.

In this article, we review existing results from physical experiments and outline their limitations, before presenting the computational model and investigating the influence of its parameters.

Impact and interest:

8 citations in Scopus
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6 citations in Web of Science®

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14 since deposited on 31 Mar 2015
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ID Code: 82666
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.jtbi.2010.02.040
ISSN: 0022-5193
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Epigenetics (incl. Genome Methylation and Epigenomics) (060404)
Australian and New Zealand Standard Research Classification > INFORMATION AND COMPUTING SCIENCES (080000) > ARTIFICIAL INTELLIGENCE AND IMAGE PROCESSING (080100) > Simulation and Modelling (080110)
Divisions: Current > Schools > School of Electrical Engineering & Computer Science
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2010 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Journal of Theoretical Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Theoretical Biology, [VOL 264, ISSUE 2, (2010)] DOI: 10.1016/j.jtbi.2010.02.040
Deposited On: 31 Mar 2015 23:37
Last Modified: 10 Apr 2015 19:19

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