Building cross-scale models of epigenetic mechanisms

Ruskin, Heather J, Perrin, Dimitri, & Roznovat, Irina A (2014) Building cross-scale models of epigenetic mechanisms. In 2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), IEEE Computer Society, pp. 30-37.

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Epigenetic changes correspond to heritable modifications of the chromosome structure, which do not involve alteration of the DNA sequence but do affect gene expression. These mechanisms play an important role in normal cell differentiation, but aberration is associated also with several diseases, including cancer and neural disorders. In consequence, despite intensive studies in recent years, the contribution of modifications remains largely unquantified due to overall system complexity and insufficient data. Computational models can provide powerful auxiliary tools to experimentation, not least as scales from the sub-cellular through cell populations (or to networks of genes) can be spanned. In this paper, the challenges to development, of realistic cross-scale models, are discussed and illustrated with respect to current work.

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ID Code: 82688
Item Type: Conference Paper
Refereed: No
Keywords: cross-scale/ multi-scale, computational modelling, DNA methylation, Epigenetics, cancer, colon crypt component
DOI: 10.1109/BIBM.2014.6999256
ISBN: 978-1-4799-5669-2/14
Divisions: Current > Schools > School of Electrical Engineering & Computer Science
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: IEEE
Deposited On: 24 Mar 2015 02:59
Last Modified: 25 Mar 2015 01:03

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