Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis
Aimes, Ronald T., Zijlstra, Andries, Hooper, John D., Ogbourne, Steven M., Sit, Mae-le, Fuchs, Simone, Gotley, David C., Quigley, James P., & Antalis, Toni M. (2003) Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis. Thrombosis and Haemostasis, 89(3), pp. 561-572.
Many serine proteases play important regulatory roles in complex biological systems, but only a few have been linked directly with capillarry morphogenesis and angiogenesis. Here we provide evidence that serine proteases activities, independent of the plasminogen activation cascade, are required for microvascular endothelial cell reorganization and capillary morphogenesis in vitro.
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