Experimental and numerical investigation of strain-rate dependent mechanical properties of single living cells
Nguyen, Trung Dung (2015) Experimental and numerical investigation of strain-rate dependent mechanical properties of single living cells. PhD thesis, Queensland University of Technology.
The objective of this project is to investigate the strain-rate dependent mechanical behaviour of single living cells using both experimental and numerical techniques. The results revealed that living cells behave as porohyperlastic materials and that both solid and fluid phases within the cells play important roles in their mechanical responses. The research reported in this thesis provides a better understanding of the mechanisms underlying the cellular responses to external mechanical loadings and of the process of mechanical signal transduction in living cells. It would help us to enhance knowledge of and insight into the role of mechanical forces in supporting tissue regeneration or degeneration.
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|Item Type:||QUT Thesis (PhD)|
|Supervisor:||Gu, YuanTong & Oloyede, Kunle|
|Keywords:||Atomic Force Microscopy, Cell biomechanics, Consolidation-dependent behaviour, Finite Element Analysis, Porohyperelastic model, Osmotic pressure, Strain-rate dependent behaviour, Stress–relaxation behaviour, Thin-layer models, Viscoelastic properties|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Institution:||Queensland University of Technology|
|Deposited On:||30 Apr 2015 06:05|
|Last Modified:||08 Sep 2015 06:19|
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