Experimental and numerical investigation of strain-rate dependent mechanical properties of single living cells

Nguyen, Trung Dung (2015) Experimental and numerical investigation of strain-rate dependent mechanical properties of single living cells. PhD thesis, Queensland University of Technology.

Abstract

The objective of this project is to investigate the strain-rate dependent mechanical behaviour of single living cells using both experimental and numerical techniques. The results revealed that living cells behave as porohyperlastic materials and that both solid and fluid phases within the cells play important roles in their mechanical responses. The research reported in this thesis provides a better understanding of the mechanisms underlying the cellular responses to external mechanical loadings and of the process of mechanical signal transduction in living cells. It would help us to enhance knowledge of and insight into the role of mechanical forces in supporting tissue regeneration or degeneration.

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62 since deposited on 30 Apr 2015
26 in the past twelve months

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ID Code: 82791
Item Type: QUT Thesis (PhD)
Supervisor: Gu, YuanTong & Oloyede, Kunle
Keywords: Atomic Force Microscopy, Cell biomechanics, Consolidation-dependent behaviour, Finite Element Analysis, Porohyperelastic model, Osmotic pressure, Strain-rate dependent behaviour, Stress–relaxation behaviour, Thin-layer models, Viscoelastic properties
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 30 Apr 2015 06:05
Last Modified: 08 Sep 2015 06:19

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