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TTYH2, a human homologue of the drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma

Rae, Fiona K., Hooper, John D., Eyre, Helen J., Sutherland, Grant R., Nicol, David L., & Clements, Judith A. (2001) TTYH2, a human homologue of the drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma. Genomics, 77(3), pp. 200-207.

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Abstract

Using differential display PCR, we identified a novel gene upregulated in renal cell carcinoma. Characterization of the full-length cDNA and gene revealed that the encoded protein is a human homologue of the Drosophila melanogaster Tweety protein, and so we have termed the novel protein TTYH2. The orthologous mouse cDNA was also identified and the predicted mouse protein is 81% identical to the human protein. The encoded human TTYH2 protein is 534 amino acids and, like the other members of the tweety-related protein family, is a putative cell surface protein with five transmembrane regions. TTYH2 is located at 17q24; it is expressed most highly in brain and testis and at lower levels in heart, ovary, spleen, and peripheral blood leukocytes. Expression of this gene is upregulated in 13 of 16 (81%) renal cell carcinoma samples examined. In addition to a putative role in brain and testis, the over-expression of TTYH2 in renal cell carcinoma suggests that it may have an important role in kidney tumorigenesis.

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12 citations in Scopus
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9 citations in Web of Science®

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ID Code: 8283
Item Type: Journal Article
Additional Information: For more information, please refer to the journal's website (see hypertext link) or contact the author. Author contact details: jd.hooper@qut.edu.au
DOI: 10.1006/geno.2001.6629
ISSN: 0888-7543
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2001 Elsevier
Deposited On: 26 Jun 2007
Last Modified: 11 Aug 2011 02:31

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