Production of biodegradable nano and micro particles via ultrasonic atomization for biopharmaceutical delivery
Forde, Gareth M. & Friend, James (2006) Production of biodegradable nano and micro particles via ultrasonic atomization for biopharmaceutical delivery. In Proceedings of the 2006 WSEAS Int. Conf. on Cellular & Molecular Biology, Biophysics & Bioengineering, Athens Greece, pp. 128-130.
Biopharmaceuticals have been shown to have low delivery and transformation efficiencies. To over come this, larger doses are administered in order to obtain the desired response which may lead to toxicity and drug resistance. This paper reports upon a continuous particle production method utilizing surface acoustic wave atomization to reliably produce micro and nanoparticles with physical characteristics to facilitate the cellular uptake of biopharmaceuticals. By producing particles of an optimal size for cellular uptake, the efficacy and specificity of drug loaded nanoparticles will be increased. Better delivery methods will result in dosage reduction (hence lower costs per dose), reduced toxicity, and reduced problems associated with multidrug resistance due to over dosing.
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|Item Type:||Conference Paper|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2006 Authors|
|Deposited On:||26 Mar 2015 03:08|
|Last Modified:||31 Mar 2015 04:39|
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