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The type II transmembrane serine protease Matriptase-2 – identification, structural features, enzymology, expression pattern and potential roles

Ramsay, Andrew J., Reid, Janet C., Velasco, Gloria, Quigley, James P., & Hooper, John D. (2008) The type II transmembrane serine protease Matriptase-2 – identification, structural features, enzymology, expression pattern and potential roles. Frontiers in Bioscience, 13(1), pp. 569-579.

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Abstract

Matriptase-2 (also known as TMPRSS6) is a recently identified member of the type II transmembrane serine protease family. Structurally this enzyme contains a short cytoplasmic amino terminal tail, a transmembrane region, a stem region containing two CUB domains and three LDL receptor class A domains, and at the carboxy terminal a trypsin-like serine protease domain. The matriptase-2 gene and encoded protein are highly conserved in mammals. Biochemically matriptase-2 has substrate specificity similar to the structurally related protein matriptase. Although the physiological function of matriptase-2 is not known, its high mRNA expression in liver and data from a limited number of studies indicating association with several cancers, it is likely that this enzyme will have important cell surface associated roles. Here we overview the identification of matriptase-2, summarise its structural features, biochemistry, expression pattern and disease associations and speculate on its potential functions.

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ID Code: 8288
Item Type: Journal Article
Additional Information: Author contact details: jd.hooper@qut.edu.au
DOI: 10.2741/2702
ISSN: 1093-9946
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2008 Frontiers in Bioscience Publications
Copyright Statement: Posted with the permission of the copyright owner for your personal use only. No further distribution is permitted without permission of the copyright owner.
Deposited On: 28 Jun 2007
Last Modified: 29 Feb 2012 23:47

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