Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis
Bray, Laura J., Binner, Marcus, Holzheu, Anja, Friedrichs, Jens, Freudenberg, Uwe, Hutmacher, Dietmar, & Werner, Carsten (2015) Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis. Biomaterials, 53, pp. 609-620.
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Tumour microenvironment greatly influences the development and metastasis of cancer progression. The development of three dimensional (3D) culture models which mimic that displayed in vivo can improve cancer biology studies and accelerate novel anticancer drug screening. Inspired by a systems biology approach, we have formed 3D in vitro bioengineered tumour angiogenesis microenvironments within a glycosaminoglycan-based hydrogel culture system. This microenvironment model can routinely recreate breast and prostate tumour vascularisation. The multiple cell types cultured within this model were less sensitive to chemotherapy when compared with two dimensional (2D) cultures, and displayed comparative tumour regression to that displayed in vivo. These features highlight the use of our in vitro culture model as a complementary testing platform in conjunction with animal models, addressing key reduction and replacement goals of the future. We anticipate that this biomimetic model will provide a platform for the in-depth analysis of cancer development and the discovery of novel therapeutic targets.
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|Item Type:||Journal Article|
|Keywords:||Angiogenesis; Cell culture; ECM; Hydrogel; Heparin; Carcinogenesis|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2015 Elsevier Ltd.|
|Copyright Statement:||NOTICE: this is the author’s version of a work that was accepted for publication in Biomaterials. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biomaterials, Volume 53, June 2015, Pages 609–620 DOI 10.1016/j.biomaterials.2015.02.124|
|Deposited On:||30 Mar 2015 04:52|
|Last Modified:||18 Jul 2015 09:43|
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